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Latest research on Gut Microbiome/Host Interactions Mediated by Metabolites

Latest research on Gut Microbiome/Host Interactions Mediated by Metabolites

Latest research on Gut Microbiome/Host Interactions Mediated by Metabolites

“The gut microbiota contributes to host physiology through the production of a myriad of metabolites. These metabolites exert their effects within the host as signalling molecules and substrates for metabolic reactions. Although the study of host–microbiota interactions remains challenging due to the high degree of crosstalk both within and between kingdoms, metabolite-focused research has identified multiple actionable microbial targets that are relevant for host health.

Metabolites, as the functional output of combined host and microorganism interactions, provide a snapshot in time of an extraordinarily complex multi-organism system. Although substantial work remains towards understanding host–microbiota interactions and the underlying mechanisms, we review the current state of knowledge for each of the major classes of microbial metabolites with emphasis on clinical and translational research implications.” (Krautkramer et. al., 2021)

What does that even mean?

It means several things;

  • Our ability to describe what is in the gut is improving
  • Our understanding of what is happening, ecologically, in the gut is improving
  • Our understanding of the myriad interactions between organisms in the gut (including the host) is very incomplete
  • We still have a long way to go before we can predict the effects of adding microbes or metabolites to the gut.

What we do know is that many people report improvements in gut comfort and function when they take LiveBrew, NZ’s only fresh, live and active probiotic.

Krautkramer, K.A., Fan, J. & Bäckhed, F. Gut microbial metabolites as multi-kingdom intermediates. Nat Rev Microbiol 19, 77–94 (2021). https://doi.org/10.1038/s41579-020-0438-4

Myth #8 Multi-strain just means different freeze-dried bacteria mixed together

Myth #8 Multi-strain just means different freeze-dried bacteria mixed together

Most freeze-dried probiotic products have a seemingly impressive list of microbes listed on the label. The assertion is then made that the product is ‘multi-strain’. While this is true in a very limited sense, it is really sidestepping the whole reason why a consumer would want a multi-strain product in the first place.

 In the real world, microbes are never alone, they never live only among their own species/strain. Microbes are always in vast communities with friends and competitors engaged in an eternal struggle for survival. Very early in the development of probiotics, it was observed that cultures containing several different microbes tended to outperform cultures containing only a single strain. These observations were generally on live active cultures, not just blends of various powdered freeze-dried bacteria.